Treatment and rehabilitation of Long COVID: A scope of the literature.:Update April 2023

Summary • We identified 18 randomised controlled trials published since December 2022 that were focused on Long COVID treatment or rehabilitation. Across our four reports produced to date, we have identified and assessed 55 trials published between January 2022 and March 2023. • A third of the trials included in this update had a primary focus on treating persistent problems with respiratory function and physical fitness (n=6). Other trials focused on olfactory dysfunction (n=5); long-term fatigue (n=2); headaches (n=1) and cognitive impairment, physical and mental fatigue and neuropsychiatric issues (n=1). Three trials evaluated interventions for treating non-specific Long COVID symptoms, all of which were focused on improving physical fitness. • Five trials were rated positively for at least 11 out of the 13 criteria that we assessed. Four trials met 10 criteria and nine gained a positive rating for between five and nine criteria.