Goralski, J.L. orcid.org/0000-0002-6785-5076, Stewart, N.J. orcid.org/0000-0001-8358-394X and Woods, J.C. (2021) Novel imaging techniques for cystic fibrosis lung disease. Pediatric Pulmonology, 56 (S1). S40-S54. ISSN 8755-6863
Abstract
With an increasing number of patients with cystic fibrosis (CF) receiving highly effective CFTR (cystic fibrosis transmembrane regulator protein) modulator therapy, particularly at a young age, there is an increasing need to identify imaging tools that can detect and regionally visualize mild CF lung disease and subtle changes in disease state. In this review, we discuss the latest developments in imaging modalities for both structural and functional imaging of the lung available to CF clinicians and researchers, from the widely available, clinically utilized imaging methods for assessing CF lung disease—chest radiography and computed tomography—to newer techniques poised to become the next phase of clinical tools—structural/functional proton and hyperpolarized gas magnetic resonance imaging (MRI). Finally, we provide a brief discussion of several newer lung imaging techniques that are currently available only in selected research settings, including chest tomosynthesis, and fluorinated gas MRI. We provide an update on the clinical and/or research status of each technique, with a focus on sensitivity, early disease detection, and possibilities for monitoring treatment efficacy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Wiley Periodicals LLC. |
Keywords: | biomarkers; cystic fibrosis (CF); imaging; Cystic Fibrosis; Humans; Lung; Magnetic Resonance Imaging; Radiography, Thoracic; Sensitivity and Specificity; Tomography, X-Ray Computed |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 31 Aug 2023 13:22 |
Last Modified: | 31 Aug 2023 13:22 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/ppul.24931 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:202804 |