Karakonstantis, S. orcid.org/0000-0002-2643-3184, Kritsotakis, E.I. orcid.org/0000-0002-9526-3852 and Gikas, A. (2021) Is pandrug-resistance in A. baumannii a transient phenotype? Epidemiological clues from a 4-year cohort study at a tertiary referral hospital in Greece. Journal of Chemotherapy, 33 (5). pp. 354-357. ISSN 1120-009X
Abstract
Pandrug-resistant A. baumannii (PDRAB) is increasingly being reported but remains rare. Several case studies show that A. baumannii can acquire resistance to last resort antibiotics during treatment by single-step chromosomal mutations. However, re-emergence of the ancestral susceptible strain after withdrawal of antibiotics has been described, possibly due to fitness cost associated with acquired resistance. Therefore, PDRAB may be a transient phenotype. Epidemiological data to show this process in larger cohorts are currently lacking. In this study of 91 hospitalized patients with PDRAB we showed the frequent (60%) isolation of non-PDRAB, often susceptible only to colistin, aminoglycosides and/or tigecycline, preceding and/or following PDRAB isolation. However, the isolation of PDRAB in two outpatients, 25 and 36 days after their discharge from the hospital, suggests the potential of some PDRAB strains to persist even in the absence of antimicrobial pressure.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Edizioni Scientifi che per l'Informazione su Farmaci e Terapia. This is an author-produced version of a paper subsequently published in Journal of Chemotherapy. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Acinetobacter baumannii; PDR; epidemiology; pandrug-resistant; resistance; Acinetobacter Infections; Acinetobacter baumannii; Aged; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Multiple, Bacterial; Female; Greece; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Tertiary Care Centers |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Aug 2023 09:24 |
Last Modified: | 11 Aug 2023 10:36 |
Status: | Published |
Publisher: | Informa UK Limited |
Refereed: | Yes |
Identification Number: | 10.1080/1120009x.2020.1839689 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:202300 |