Denis, Dan orcid.org/0000-0003-3740-7587, Bottary, Ryan, Cunningham, Tony J et al. (2 more authors) (2023) Beta spectral power during sleep is associated with impaired recall of extinguished fear. Sleep. ISSN 1550-9109
Abstract
The failure to retain memory for extinguished fear plays a major role in the maintenance of post-traumatic stress disorder (PTSD), with successful extinction recall necessary for symptom reduction. Disturbed sleep, a hallmark symptom of PTSD, impairs fear extinction recall. However, our understanding of the electrophysiological mechanisms underpinning sleep's role in extinction retention remain underdetermined. We examined the relationship between the microarchitecture of sleep and extinction recall in healthy humans (n=71, both male and females included) and a pilot study in individuals with PTSD (n=12). Participants underwent a fear conditioning and extinction protocol over two days, with sleep recording occurring between conditioning and extinction. Twenty-four hours after extinction learning, participants underwent extinction recall. Power spectral density (PSD) was computed for pre- and post-extinction learning sleep. Increased beta band PSD (~17-26Hz) during pre-extinction learning sleep was associated with worse extinction recall in healthy participants (r=.41, p=.004). Beta PSD was highly stable across three nights of sleep (intraclass correlations (ICC)>0.92). Results suggest beta band PSD is elevated in PTSD, and is specifically implicated in difficulties recalling extinguished fear.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2023. Published by Oxford University Press on behalf of Sleep Research Society. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 08 Aug 2023 08:40 |
Last Modified: | 27 Feb 2025 00:07 |
Published Version: | https://doi.org/10.1093/sleep/zsad209 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1093/sleep/zsad209 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:202261 |