Stewart, N.J. orcid.org/0000-0001-8358-394X, Higano, N.S. orcid.org/0000-0002-6233-161X, Mukthapuram, S. et al. (9 more authors) (2023) Initial feasibility and challenges of hyperpolarized 129Xe MRI in neonates with bronchopulmonary dysplasia. Magnetic Resonance in Medicine, 90 (6). pp. 2420-2431. ISSN 0740-3194
Abstract
Purpose The underlying functional and microstructural lung disease in neonates who are born preterm (bronchopulmonary dysplasia, BPD) remains poorly characterized. Moreover, there is a lack of suitable techniques to reliably assess lung function in this population. Here, we report our preliminary experience with hyperpolarized 129Xe MRI in neonates with BPD.
Methods Neonatal intensive care patients with established BPD were recruited (N = 9) and imaged at a corrected gestational age of median:40.7 (range:37.1, 44.4) wk using a 1.5T neonatal scanner. 2D 129Xe ventilation and diffusion-weighted images and dissolved phase spectroscopy were acquired, alongside 1H 3D radial UTE. 129Xe images were acquired during a series of short apneic breath-holds (˜3 s). 1H UTE images were acquired during tidal breathing. Ventilation defects were manually identified and qualitatively compared to lung structures on UTE. ADCs were calculated on a voxel-wise basis. The signal ratio of the 129Xe red blood cell (RBC) and tissue membrane (M) resonances from spectroscopy was determined.
Results Spiral-based 129Xe ventilation imaging showed good image quality and sufficient sensitivity to detect mild ventilation abnormalities in patients with BPD. 129Xe ADC values were elevated above that expected given healthy data in older children and adults (median:0.046 [range:0.041, 0.064] cm2s−1); the highest value obtained from an extremely pre-term patient. 129Xe spectroscopy revealed a low RBC/M ratio (0.14 [0.06, 0.21]).
Conclusion We have demonstrated initial feasibility of 129Xe lung MRI in neonates. With further data, the technique may help guide management of infant lung diseases in the neonatal period and beyond.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: | bronchopulmonary dysplasia; hyperpolarized 129Xe; lung MRI; neonatal MRI |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Aug 2023 09:29 |
Last Modified: | 04 Oct 2024 14:12 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/mrm.29808 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:202181 |
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