Put, Piotr, Alcicek, Seyma, Bondar, Oksana et al. (3 more authors) (2023) Detection of pyridine derivatives by SABRE hyperpolarization at zero field. Communications Chemistry. 131. ISSN 2399-3669
Abstract
Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical tool used in modern science and technology. Its novel incarnation, based on measurements of NMR signals without external magnetic fields, provides direct access to intramolecular interactions based on heteronuclear scalar J-coupling. The uniqueness of these interactions makes each zero-field NMR spectrum distinct and useful in chemical fingerprinting. However, the necessity of heteronuclear coupling often results in weak signals due to the low abundance of certain nuclei (e.g., 15N). Hyperpolarization of such compounds may solve the problem. In this work, we investigate molecules with natural isotopic abundance that are polarized using non-hydrogenative parahydrogen-induced polarization. We demonstrate that spectra of hyperpolarized naturally abundant pyridine derivatives can be observed and uniquely identified whether the same substituent is placed at a different position of the pyridine ring or different constituents are placed at the same position. To do so, we constructed an experimental system using a home-built nitrogen vapor condenser, which allows for consistent long-term measurements, crucial for identifying naturally abundant hyperpolarized molecules at a concentration level of ~1 mM. This opens avenues for future chemical detection of naturally abundant compounds using zero-field NMR.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Funding Information: The authors acknowledge support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 766402. P.P. and S.A. acknowledge the support of a grant from the SciMat Priority Research Area under the Strategic Programme Excellence Initiative at the Jagiellonian University. Publisher Copyright: © 2023, The Author(s). |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION 766402 |
Depositing User: | Pure (York) |
Date Deposited: | 04 Aug 2023 10:20 |
Last Modified: | 16 Oct 2024 19:20 |
Published Version: | https://doi.org/10.1038/s42004-023-00928-z |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1038/s42004-023-00928-z |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:202131 |