Maliszewska, H.K. orcid.org/0000-0002-5452-5457, Abdelhamid, M.A.S. orcid.org/0000-0002-1247-9915, Marín, M.J. orcid.org/0000-0001-8021-5498 et al. (2 more authors) (2023) Anticancer activity and DNA interaction of bis(pyridyl)allene-derived metal complexes. Pure and Applied Chemistry, 95 (4). pp. 377-388. ISSN 0033-4545
Abstract
The constant need for novel drugs has prompted the scientific community to explore alternative structures to natural products and small and medium size organic compounds used in classic medicinal and pharmaceutical chemistry. Since the discovery of cisplatin, organometallic compounds have revealed great potential as metallodrugs and their development has exponentially grown in recent years. In this manuscript, we describe our efforts towards the synthesis of new metallodrugs by reaction of bis(pyridyl)allenes and metal complexes. Two classes of compounds are presented: one in which the allene structure is intact and the metal (Pd(II), Pt(IV) or Au(III)) coordinates to the pyridine-nitrogens; and another, in which one of the pyridines cyclises into a gold-activated allene to form β-N-stabilised gold carbenes. Both classes of compounds are active catalysts in important organic reactions, and are also promising antimicrobial, antifungal and anticancer agents. In this work, we describe the promising anticancer activity, against breast cancer cells, of the gold carbene complexes, and preliminary studies of their interaction with DNA, including non-canonical DNA structures. Our results have revealed an unusual selective stabilisation of hTeloC i-motif by one of the Au(III) carbene complexes, that opens up exciting opportunities for further development of novel DNA-binding metallodrugs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Keywords: | anticancer; DNA interaction; gold carbenes; ICPOC-25; metallodrugs |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 24 Jul 2023 15:20 |
Last Modified: | 24 Jul 2023 15:20 |
Status: | Published |
Publisher: | Walter de Gruyter GmbH |
Refereed: | Yes |
Identification Number: | 10.1515/pac-2023-0212 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:201835 |