Milkova, V. orcid.org/0000-0002-6737-1936 and Goycoolea, F.M. (Cover date: July 14, 2023) Polysaccharide‐Stabilized Capsules for Delivery of Indomethacin. ChemistrySelect, 8 (26). e202204420. ISSN 2365-6549
Abstract
Indomethacin was encapsulated in oil-core capsules stabilized by carrageenan/chitosan film formed through subsequent electrostatic adsorption of oppositely charged polysaccharides on lecithin-stabilized oil-in-water emulsion droplets. In order to investigate the influence of the physicochemical properties of polysaccharides on drug encapsulation, chitosan samples with different degrees of acetylation (DA) and molecular weight (Mw) were chosen in this study. The variation of the electrokinetic charge and hydrodynamic diameter of the droplets were measured after each adsorption step by Dynamic light scattering. The experimental results indicated that the diameter of the loaded capsules and encapsulation efficiency of the drug (in the range of 70 %–94 %) depend on the Mw of the chitosan. The electrokinetic measurements indicated the achievement of overcompensation of the surface charge and re-stabilization of the dispersion after each deposition step.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is the peer reviewed version of the following article: Milkova, V., Goycoolea, F. M., ChemistrySelect 2023, 8, e202204420., which has been published in final form at https://doi.org/10.1002/slct.202204420. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 19 Jul 2023 10:35 |
Last Modified: | 13 Jul 2024 00:13 |
Published Version: | https://chemistry-europe.onlinelibrary.wiley.com/d... |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/slct.202204420 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:201686 |