Saleban, M., Harris, E.L. and Poulter, J.A. orcid.org/0000-0003-2048-5693 (2023) D-Type Cyclins in Development and Disease. Genes, 14 (7). 1445. ISSN 2073-4425
Abstract
D-type cyclins encode G1/S cell cycle checkpoint proteins, which play a crucial role in defining cell cycle exit and progression. Precise control of cell cycle exit is vital during embryonic development, with defects in the pathways regulating intracellular D-type cyclins resulting in abnormal initiation of stem cell differentiation in a variety of different organ systems. Furthermore, stabilisation of D-type cyclins is observed in a wide range of disorders characterized by cellular over-proliferation, including cancers and overgrowth disorders. In this review, we will summarize and compare the roles played by each D-type cyclin during development and provide examples of how their intracellular dysregulation can be an underlying cause of disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | cyclin D1; cyclin D2; cyclin D3; CDK4; cell cycle; proliferation; cancer; overgrowth |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Molecular Medicine |
Funding Information: | Funder Grant number UKRI (UK Research and Innovation) MR/T02044X/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Jul 2023 10:03 |
Last Modified: | 18 Jul 2023 10:03 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/genes14071445 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:201569 |