Downey, C.L. orcid.org/0000-0001-9818-8002, Bainbridge, J., Jayne, D.G. orcid.org/0000-0002-8725-3283 et al. (1 more author) (2023) Impact of in-hospital postoperative complications on quality of life up to 12 months after major abdominal surgery. British Journal of Surgery, 110 (9). pp. 1206-1212. ISSN 0007-1323
Abstract
Background Postoperative complications are common, but there are limited data regarding their implications on patients’ quality of life. This study aimed to address this gap in the literature by analysing the impact of postoperative complications on patients’ health-related quality of life.
Methods Data from the Perioperative Quality Improvement Programme were analysed, and included patient-level data for 19 685 adults who underwent elective major abdominal procedures in England since 2016. Postoperative complications were graded using the Clavien–Dindo classification. Quality of life was assessed by responses to the EuroQol five-dimension five-levels-of-response (EQ-5D-5L™) questionnaire before surgery, and at 6 and 12 months after operation. Ordinal logistic regression was used to estimate the association between Clavien–Dindo grades and quality of life. Tobit and ordinary least squares regression analyses were used to estimate the quality-adjusted life-year (QALY) loss resulting from postoperative complications between admission and 12 months after surgery.
Results At 6 and 12 months after surgery, increasingly severe postoperative complications were significantly associated with poorer health-related quality of life. The effect of postoperative complications on quality of life was sustained until at least 12 months after operation. Between admission and 12 months after surgery, 0.012, 0.026, 0.033, and 0.086 QALYs were lost for those experiencing a grade I, II, III, or IV postoperative complication respectively.
Conclusion Postoperative complications have a significant and sustained effect on patients’ quality of life after surgery; this effect worsens as the severity of the complications increases.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2023. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Medical Research (LIMR) > Division of Gastroenterology and Surgery |
Funding Information: | Funder Grant number Leeds Hospitals Charity A2001693 |
Depositing User: | Symplectic Publications |
Date Deposited: | 10 Jul 2023 10:39 |
Last Modified: | 15 Jan 2024 13:16 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/bjs/znad167 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:201340 |