Buksa, H., Neal, T.J., Varlas, S. orcid.org/0000-0002-4171-7572 et al. (3 more authors) (2023) Synthesis and characterization of charge-stabilized poly(4-hydroxybutyl acrylate) latex by RAFT aqueous dispersion polymerization: a new precursor for reverse sequence polymerization-induced self-assembly. Macromolecules, 56 (11). pp. 4296-4306. ISSN 0024-9297
Abstract
The reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 4-hydroxybutyl acrylate (HBA) is conducted using a water-soluble RAFT agent bearing a carboxylic acid group. This confers charge stabilization when such syntheses are conducted at pH 8, which leads to the formation of polydisperse anionic PHBA latex particles of approximately 200 nm diameter. The weakly hydrophobic nature of the PHBA chains confers stimulus-responsive behavior on such latexes, which are characterized by transmission electron microscopy, dynamic light scattering, aqueous electrophoresis, and 1H NMR spectroscopy. Addition of a suitable water-miscible hydrophilic monomer such as 2-(N-(acryloyloxy)ethyl pyrrolidone) (NAEP) leads to in situ molecular dissolution of the PHBA latex, with subsequent RAFT polymerization leading to the formation of sterically stabilized PHBA-PNAEP diblock copolymer nanoparticles of approximately 57 nm diameter. Such formulations constitute a new approach to reverse sequence polymerization-induced self-assembly, whereby the hydrophobic block is prepared first in aqueous media.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Authors. Published by American Chemical Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Bioengineering; Nanotechnology |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL EP/R003009/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Jul 2023 12:44 |
Last Modified: | 04 Jul 2023 12:44 |
Published Version: | http://dx.doi.org/10.1021/acs.macromol.3c00534 |
Status: | Published |
Publisher: | American Chemical Society (ACS) |
Refereed: | Yes |
Identification Number: | 10.1021/acs.macromol.3c00534 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:201128 |