Berberolli, S, Collado-González, M, González-Espinosa, Y et al. (3 more authors) (2023) Derivatized chitosan-oil-in-water nanocapsules for trans-cinnamaldehyde delivery. International Journal of Biological Macromolecules, 240. 124464. ISSN 0141-8130
Abstract
trans-Cinnamaldehyde, known for its bacterial anti-quorum sensing activity when applied at sublethal concentrations, has gained traction given its potential use against multidrug resistant bacteria. In this work, trans-cinnamaldehyde-loaded oil-in-water nanocapsules coated with chitosan, N,N,N-trimethyl chitosan chloride, N-(2-(N,N,N-trimethylammoniumyl)acetyl) chitosan chloride or N-(6-(N,N,N-trimethylammoniumyl)hexanoyl)chitosan chloride were obtained. All the formulated nanocapsules showed a Z-average hydrodynamic diameter ~ 160 nm and ζ-potential higher than +40 mV. N,N,N-trimethyl chitosan-coated oil-in-water nanocapsules showed the greatest trans-cinnamaldehyde association efficiency (99.3 ± 7.6) % and total payload release (88.6 ± 22.5) %, while N-(6-(N,N,N-trimethylammoniumyl)hexanoyl)chitosan chloride chitosan-coated oil-in-water nanocapsules were the only formulations stable in phosphate buffer saline PBS (pH 7.4) upon incubation at 37 °C for 24 h. Future work should address the stability of the developed nanocapsules in culture media and their biological performance.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 Published by Elsevier B.V. This is an author produced version of an article published in International Journal of Biological Macromolecules. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Chitosan, Oil-in-water nanocapsules, trans-Cinnamaldehyde, Stability, Dynamic light scattering, Bacterial quorum sensing |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Jul 2023 10:07 |
Last Modified: | 21 Apr 2024 00:13 |
Status: | Published |
Publisher: | Elsevier BV |
Identification Number: | 10.1016/j.ijbiomac.2023.124464 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:201101 |