Tang, B.-C. orcid.org/0000-0001-8779-1498, Wang, Y.-T. orcid.org/0000-0002-8879-8701 and Ren, J. (2023) Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications. Ibrain, 9 (3). pp. 340-348. ISSN 2769-2795
Abstract
Memantine is a noncompetitive moderate-affinity strong voltage-dependent N-methyl-D-aspartate receptor antagonist. It has been used to treat Alzheimer's disease (AD) since 1989. In 2018, it became the second most commonly used drug for the treatment of dementia in the world. AD is nonreversible, and memantine can only relieve the symptoms of AD but not cure it. Over the past half-century, memantine's research and clinical application have been extensively developed. In this review, the basic composition of memantine, the mechanism and limitations of memantine in the treatment of AD, memantine combination therapy, comparison of memantine with other drugs for AD, and clinical studies of memantine in other diseases are reviewed to provide a valuable reference for further research and application of memantine for the treatment of AD.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Authors. Ibrain published by Affiliated Hospital of Zunyi Medical University (AHZMU) and Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Neurodegenerative; Aging; Neurosciences; Alzheimer's Disease; Acquired Cognitive Impairment; Dementia; Brain Disorders; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Clinical Trials and Supportive Activities; Clinical Research; 6 Evaluation of treatments and therapeutic interventions; 5 Development of treatments and therapeutic interventions; 6.1 Pharmaceuticals; 5.1 Pharmaceuticals; Neurological |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Jun 2023 16:16 |
Last Modified: | 03 Oct 2024 15:18 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/ibra.12098 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:200351 |