Schini, M. orcid.org/0000-0003-2204-2095, Vilaca, T. orcid.org/0000-0002-9227-6076, Gossiel, F. orcid.org/0000-0002-1433-2001 et al. (2 more authors) (2023) Bone turnover markers: basic biology to clinical applications. Endocrine Reviews, 44 (3). pp. 417-473. ISSN 0163-769X
Abstract
Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the last 20 years, much experience has been gained in measurement and interpretation of these markers, which include commonly used bone formation markers (bone alkaline phosphatase, osteocalcin, and procollagen I N-propeptide); and commonly used resorption markers (serum C-telopeptides of type I collagen, urinary N-telopeptides of type I collagen, and tartrate-resistant acid phosphatase type 5b). BTMs are usually measured by enzyme-linked immunosorbent assay or automated immunoassay. Sources contributing to BTM variability include uncontrollable factors (eg, age, gender, ethnicity) and controllable factors, particularly relating to collection conditions (eg, fasting/feeding state, and timing relative to circadian rhythms, menstrual cycling, and exercise). Pregnancy, season, drugs, and recent fracture(s) can also affect BTMs. BTMs correlate with other methods of assessing bone turnover, such as bone biopsies and radiotracer kinetics, and can usefully contribute to diagnosis and management of several diseases such as osteoporosis, osteomalacia, Paget’s disease, fibrous dysplasia, hypophosphatasia, primary hyperparathyroidism, and chronic kidney disease–mineral bone disorder.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons. org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. |
Keywords: | C-telopeptides of type I collagen; biochemical markers of bone turnover; bone alkaline phosphatase; osteocalcin; tartrate-resistant acid phosphatase 5b; urinary N-telopeptides of type I collagen; Humans; Collagen Type I; Acid Phosphatase; Alkaline Phosphatase; Bone Remodeling; Biology; Bone Resorption |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL MR/P020941/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Jun 2023 13:25 |
Last Modified: | 09 Jun 2023 13:25 |
Status: | Published |
Publisher: | The Endocrine Society |
Refereed: | Yes |
Identification Number: | 10.1210/endrev/bnac031 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:199651 |