Ladbury, JE orcid.org/0000-0002-6328-7200, Lin, C-C orcid.org/0000-0003-3071-172X and Suen, KM (2023) Phase separation enhances probability of receptor signalling and drug targeting. Trends in Biochemical Sciences, 48 (5). pp. 428-436. ISSN 0167-7640
Abstract
The probability of a given receptor tyrosine kinase (RTK) triggering a defined cellular outcome is low because of the promiscuous nature of signalling, the randomness of molecular diffusion through the cell, and the ongoing nonfunctional submembrane signalling activity or noise. Signal transduction is therefore a ‘numbers game’, where enough cell surface receptors and effector proteins must initially be engaged to guarantee formation of a functional signalling complex against a background of redundant events. The presence of intracellular liquid–liquid phase separation (LLPS) at the plasma membrane provides a mechanism through which the probabilistic nature of signalling can be weighted in favour of the required, discrete cellular outcome and mutual exclusivity in signal initiation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 The Author(s). This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | protein condensate, phase separation kinase signalling, protein droplet |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Plant Cell & Cellular Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 May 2023 13:23 |
Last Modified: | 23 May 2023 13:23 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.tibs.2023.01.005 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:199464 |