Wang, H, Lu, W, Ke, L orcid.org/0000-0002-4358-2210 et al. (3 more authors) (2022) Effect of hydroxychloroquine sulfate on the gelation behavior, water mobility and structure of gelatin. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 633 (Part 2). 127849. ISSN 0927-7757
Abstract
Hydroxychloroquine sulfate (HCQ) is a well-established antimalarial drug that has received considerable attention during the COVID-19 associated pneumonia epidemic. Gelatin is a multifunctional biomacromolecule with pharmaceutical applications and can be used to deliver HCQ. The effect of HCQ on the gelation behaviors, water mobility, and structure of gelatin was investigated to understand the interaction between the drug and its delivery carrier. The gel strength, hardness, gelling (Tg) and melting (Tm) temperatures, gelation rate (kgel), and water mobility of gelatin decreased with increasing amounts of HCQ. The addition of HCQ led to hydrogen bonding that interfered with triple helix formation in gelatin. Fourier transform infrared spectroscopy (FTIR) and X-ray diffractometer (XRD) analysis further confirmed that the interaction between HCQ and gelatin is primarily through hydrogen bonding. Atomic force microscopy (AFM) revealed that higher content of HCQ resulted in more and larger aggregates in gelatin. These results provide not only an important understanding of gelatin for drug delivery design but also a basis for the studying interactions between a drug and its delivery carrier.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Keywords: | Gelatin; Hydroxychloroquine sulfate (HCQ); Gelation behavior; Structure; Interaction |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 May 2023 15:35 |
Last Modified: | 26 May 2023 15:35 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.colsurfa.2021.127849 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:199418 |