Wang, H, Huang, J, Ding, Y et al. (8 more authors) (2022) Nanoparticles Isolated From Porcine Bone Soup Ameliorated Dextran Sulfate Sodium-Induced Colitis and Regulated Gut Microbiota in Mice. Frontiers in Nutrition, 9.
Abstract
Daily foods contain a great number of self-assembled nanoparticles (NPs) which were
incidentally produced during food processing. These food incidental NPs can directly
access the human gastrointestinal tract in high frequency and large quantities. Limited
reports were focused on whether and how these food incidental NPs affected the
gastrointestinal tissues and gut microbiota. In the present study, bone soup and its
NPs both significantly ameliorated colitis symptoms in dextran sulfate sodium (DSS)-
induced mice and inhibited the release of pro-inflammatory cytokines. They also restored
intestinal microbiota dysbiosis by improving the diversity and richness of intestinal
microbiota and regulating community composition, such as a remarkable increase in
Muribaculaceae, Alistipes, and Alloprevotella, and a decrease in Helicobacter. Moreover,
the correlation analysis showed that pro-inflammatory cytokines were negatively
correlated with Muribaculaceae, Alloprevotella, and Alistipes, but positively correlated
with Helicobacter. These findings suggest that the food incidental NPs can influence
human health through regulating the inflammation of the gastrointestinal tissues and the
gut microbiota
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 Wang, Huang, Ding, Zhou, Gao, Han, Zhou, Ke, Rao, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Keywords: | Bone soup, nanoparticles, ulcerative colitis, gut microbiota, inflammation, dextran sulfate sodium |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 May 2023 14:13 |
Last Modified: | 26 May 2023 14:13 |
Published Version: | http://dx.doi.org/10.3389/fnut.2022.821404 |
Status: | Published |
Publisher: | Frontiers Media SA |
Identification Number: | 10.3389/fnut.2022.821404 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:199355 |