Perrone, R.D. orcid.org/0000-0002-4963-1132, Oberdhan, D. orcid.org/0000-0003-1034-9049, Ouyang, J. et al. (9 more authors) (2023) OVERTURE: A worldwide, prospective, observational study of disease characteristics in patients with ADPKD. Kidney International Reports, 8 (5). pp. 989-1001. ISSN 2468-0249
Abstract
Introduction
The course of autosomal dominant polycystic kidney disease (ADPKD) varies greatly among affected individuals, necessitating natural history studies to characterize the determinants and effects of disease progression. Therefore, we conducted an observational, longitudinal study (OVERTURE; NCT01430494) of patients with ADPKD. Methods This prospective study enrolled a large international population (N = 3409) encompassing a broad spectrum of ages (12–78 years), chronic kidney disease (CKD) stages (G1–G5), and Mayo imaging classifications (1A–1E). Outcomes included kidney function, complications, quality of life, health care resource utilization, and work productivity.
Results
Most subjects (84.4%) completed ≥12 months of follow-up. Consistent with earlier findings, each additional l/m of height-adjusted total kidney volume (htTKV) on magnetic resonance imaging (MRI) was associated with worse outcomes, including lower estimated glomerular filtration rate (eGFR) (regression coefficient 17.02, 95% confidence interval [CI] 15.94–18.11) and greater likelihood of hypertension (odds ratio [OR] 1.25, 95% CI 1.17–1.34), kidney pain (OR 1.22, 95% CI 1.11–1.33), and hematuria (OR 1.35, 95% CI 1.21–1.51). Greater baseline htTKV was also associated with worse patient-reported health-related quality of life (e.g., ADPKD Impact Scale physical score, regression coefficient 1.02, 95% CI 0.65–1.39), decreased work productivity (e.g., work days missed, regression coefficient 0.55, 95% CI 0.18–0.92), and increased health care resource utilization (e.g., hospitalizations, OR 1.48, 95% CI 1.33–1.64) during follow-up.
Conclusion
Although limited by a maximum 3-year duration of follow-up, this observational study characterized the burden of ADPKD in a broad population and indicated the predictive value of kidney volume for outcomes other than kidney function.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2023 International Society of Nephrology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | autosomal dominant polycystic kidney disease; cohort; disease progression; natural; history; observational; patient-reported outcomes |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 May 2023 10:36 |
Last Modified: | 10 May 2023 10:36 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.ekir.2023.02.1073 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:198998 |