The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

This is a preprint and may not have undergone formal peer review

Abstract

We identify amino acid variants within dominant SARS-CoV-2 T-cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T-cells assessed by IFN-γ and cytotoxic killing assays. These data demonstrate the potential for T-cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T-cell as well as humoral immunity.

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Item Type:	Preprint
Authors/Creators:	de Silva, T.I. https://orcid.org/0000-0002-6498-9212 Liu, G. B Lindsey, B. Dong, D. Shah, D. J. Mentzer, A. Angyal, A. Brown, R. D. Parker, M. https://orcid.org/0000-0003-2999-3870 Ying, Z. Yao, X. Turtle, L. Dunachie, S. K. Maini, M. Ogg, G. Knight, J.C. Peng, Y. Rowland-Jones, S.L. https://orcid.org/0000-0001-5788-6998 Dong, T.
Copyright, Publisher and Additional Information:	© 2021 The Author(s). This preprint is made available under a Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
Keywords:	COVID-19 Genomics UK (COG-UK) Consortium
Dates:	Submitted: 8 April 2021
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease
Funding Information:	Funder Grant number National Institute for Health Research IS-BRC-1215-20017 WELLCOME TRUST (THE) 110058/A/15/Z MEDICAL RESEARCH COUNCIL MR/V028448/1
Depositing User:	Symplectic Sheffield
Date Deposited:	05 May 2023 16:04
Last Modified:	05 May 2023 16:04
Published Version:	http://dx.doi.org/10.1101/2021.04.08.438904
Status:	Submitted
Publisher:	Cold Spring Harbor Laboratory
Identification Number:	10.1101/2021.04.08.438904
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:198942

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The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

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