Rabetafika, HN, Razafindralambo, A, Ebenso, B orcid.org/0000-0003-4147-0968 et al. (1 more author) (2023) Probiotics as Antibiotic Alternatives for Human and Animal Applications. Encyclopedia, 3 (2). pp. 561-581. ISSN 2673-8392
Abstract
Probiotics are live microorganisms recognized as natural candidates to substitute antibiotic substances, usually used to treat bacterial infections responsible for numerous human and animal diseases. Antibiotics are mostly prescribed for treating infections caused by bacteria. However, their excessive and inappropriate use has resulted in the increase of bacterial antimicrobial resistance (AMR) and host microbiota imbalance or dysbiosis phenomena. Even though antibiotics are the most well-known lifesaving substances, the AMR within the bacterial community has become a growing threat to global health, with the potential to cause millions of deaths each year in the future. Faced with these worldwide issues, it is high time to discover and develop antibiotic alternatives. There exists some evidence of probiotic roles in antagonizing pathogens, modulating immune systems, and maintaining general host health by restoring the gut microbiota balance. The multi-antimicrobial action mechanisms of such beneficial living microorganisms are one approach to practicing the “prevention is better than cure” concept to avoid antibiotics. The current review proposes a comprehensive description of antibiotic-related AMR issues and the potential of probiotics as antibiotic alternatives, while discussing pros and cons, as well as some evidence of beneficial uses of probiotics for human and animal health protection through recent results of experimental models and clinical trials.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 by the authors. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | antimicrobial resistance; immunomodulation; gut microbiota; bacteriocins; human health; animal health |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Nuffield Centre for International Health and Development (Leeds) |
Funding Information: | Funder Grant number EU - European Union 10040479 |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 May 2023 10:12 |
Last Modified: | 25 Jun 2023 23:20 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/encyclopedia3020040 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:198884 |