Gallagher, H, Hendrickse, PW, Pereira, MG et al. (1 more author) (2023) Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training. Journal of Sport and Health Science, 12 (5). pp. 557-567. ISSN 2095-2546
Abstract
This review highlights some established and some more contemporary mechanisms responsible for heart failure-induced skeletal muscle wasting and weakness. We first describe the effects of heart failure on the relationship between protein synthesis and degradation rates, which determine muscle mass, the involvement of the satellite cells for continual muscle regeneration, and changes in myofiber calcium homeostasis linked to contractile dysfunction. We then highlight key mechanistic effects of both aerobic and resistance exercise training on skeletal muscle in heart failure and outline its application as a beneficial treatment. Overall, heart failure causes multiple impairments related to autophagy, anabolic-catabolic signaling, satellite cell proliferation, and calcium homeostasis, which together promote fiber atrophy, contractile dysfunction, and impaired regeneration. Although both wasting and weakness are partly rescued by aerobic and resistance exercise training in heart failure, the effects of satellite cell dynamics remain poorly explored.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 Published by Elsevier B.V. This is an author produced version of an article published in Journal of Sport and Health Science. Uploaded in accordance with the publisher's self-archiving policy. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
Keywords: | Heart failure; Skeletal muscle wasting; Exercise training; Calcium; Satellite cells |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number Heart Research UK RG2683/19/21 British Heart Foundation Not Known |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Apr 2023 09:03 |
Last Modified: | 22 Nov 2023 14:52 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jshs.2023.04.001 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:198536 |