Coizet, V., Al Tannir, R., Pautrat, A. et al. (1 more author) (2024) Separation of channels subserving approach and avoidance/escape at the level of the basal ganglia and related brainstem structures. Current Neuropharmacology, 22 (9). pp. 1473-1490. ISSN 1570-159X
Abstract
The basal ganglia have a key function of directing our behavior in the context of events from our environment and/or our internal state. This function relies on afferents targeting the main input structures of the basal ganglia, entering bids for action selection at the level of the striatum, or signals for behavioral interruption at the level of the subthalamic nucleus, with behavioral reselection facilitated by dopamine signaling. Numerous experiments have studied action selection in relation to inputs from the cerebral cortex, however less is known about the anatomical and functional link between the basal ganglia and the brainstem. In this review, we describe how brainstem structures also project to the main input structures of the basal ganglia, namely the striatum, the subthalamic nucleus and midbrain dopaminergic neurons, in the context of approach and avoidance (including escape from threat), two fundamental, mutually exclusive behavioral choices in an animal’s repertoire in which the brainstem is strongly involved. We focus on three particularly well described loci involved in approach and avoidance, namely the superior colliculus, the parabrachial nucleus and the periaqueductal grey nucleus. We consider what is known about how these structures are related to the basal ganglia, focusing on their projections toward the striatum, dopaminergic neurons and subthalamic nucleus, and explore the functional consequences of those interactions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 Bentham Science Publishers. This is an author-produced version of a paper subsequently published in Current Neuropharmacology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Basal ganglia; cerebral cortex; brainstem; neurotransmitter; striatum; approach and avoidance |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Funding Information: | Funder Grant number Medical Research Council 164088 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 06 Apr 2023 15:44 |
Last Modified: | 04 Oct 2024 14:13 |
Status: | Published |
Publisher: | Bentham Science Publishers |
Refereed: | Yes |
Identification Number: | 10.2174/1570159X21666230818154903 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:197829 |