Ismail, Vian, Britt, Hannah, Mosely, Jackie orcid.org/0000-0002-9706-1197 et al. (1 more author) (2021) Peptide lipidation in lysophospholipid micelles and lysophospholipid-enriched membranes. FARADAY DISCUSSIONS. pp. 282-294. ISSN 1364-5498
Abstract
Acyl transfer from lipids to membrane-associated peptides is a well-documented process, leading to the generation of a lipidated peptide and a lysolipid. In this article, we demonstrate that acyl transfer from lysophosphatidylcholines (lysoPCs) to the peptide melittin also occurs, both in micelles of pure lysolipid and in lipid/lysolipid mixtures. In the case of bilayers containing lysolipids, acyl transfer from the lysolipid is marginally favoured over transfer from the lipid. In pure bilayers of saturated lipids, the introduction of even small amounts of lysolipid appears to significantly increase the reactivity towards lipidation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2021 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 17 Mar 2023 09:30 |
Last Modified: | 16 Oct 2024 19:07 |
Published Version: | https://doi.org/10.1039/d1fd00030f |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/d1fd00030f |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:197465 |
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Description: Peptide lipidation in lysophospholipid micelles and lysophospholipid-enriched membranes
Licence: CC-BY 2.5