Ashwin, Helen, Milross, Luke, Wilson, Julie orcid.org/0000-0002-5171-8480 et al. (11 more authors) (2023) Identification of a protein expression signature distinguishing early from organising diffuse alveolar damage in COVID-19 patients. Journal of clinical pathology. ISSN 0021-9746
Abstract
Diffuse alveolar damage (DAD) is the histological expression of acute respiratory distress syndrome and characterises lung pathology due to infection with SARS-CoV-2, and other respiratory pathogens of clinical significance. DAD reflects a time-dependent immunopathological process, progressing from an early/exudative stage through to an organising/fibrotic stage, yet within an individual these different stages of DAD may coexist. Understanding the progression of DAD is central to the development of new therapeutics to limit progressive lung damage. Here, we applied highly multiplexed spatial protein profiling to autopsy lung tissues derived from 27 patients who died from COVID-19 and identified a protein signature (ARG1, CD127, GZMB, IDO1, Ki67, phospho-PRAS40 (T246) and VISTA) that distinguishes early DAD from late DAD with good predictive accuracy. These proteins warrant further investigation as potential regulators of DAD progression.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Author(s) (or their employer(s)) 2023 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Mathematics (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 13 Mar 2023 12:50 |
Last Modified: | 22 Oct 2024 00:07 |
Published Version: | https://doi.org/10.1136/jcp-2023-208771 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1136/jcp-2023-208771 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:197269 |