Ahmed, B., Arjmandi-Tash, O., Litster, J.D. et al. (1 more author) (2023) Mechanistic modelling of spherical agglomeration processes. Powder Technology, 417. 118254. ISSN 0032-5910
Abstract
Spherical agglomeration is emerging as an important unit process for pharmaceutical manufacturing. However, at present, quantitative process design to control agglomerate attributes is impossible. A new population balance model to predict agglomerate attributes is presented where for the first time, all of the key rate processes that control agglomerate properties are included. A parameter sensitivity analysis is undertaken to study the effect of process parameters on agglomerate attributes. Bridging liquid droplet size and bridging liquid to solids ratio (BSR) are critical controlling parameters. Good quality agglomerates are formed over a relatively narrow range of BSR. Within this range, bridging liquid droplet size can be used to tune agglomerate size. Primary crystal size and process mixing intensity have only a modest effect on equilibrium agglomerate attributes but do impact agglomerate formation kinetics. This new model provides the basis for improved process understanding and quantitative process design of spherical agglomeration.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 Elsevier. This is an author produced version of a paper subsequently published in Powder Technology. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | Spherical agglomeration; Population balance model; Mechanistic understanding; Agglomerate size and size distribution; Average liquid volume fraction |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL EP/P006965/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Mar 2023 16:06 |
Last Modified: | 16 Jan 2024 01:13 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.powtec.2023.118254 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:197246 |
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Filename: Mechanistic Modelling of Spherical Agglomeration Processes Accepted Manuscript.pdf
Licence: CC-BY-NC-ND 4.0