Autologous haematopoietic stem cell transplantation for immune-mediated neurological diseases: what, how, who and why?

Abstract

In carefully selected patients, autologous haematopoietic stem cell transplantation (HSCT) is a safe, highly effective and cost-saving treatment modality for treatment-resistant, and potentially treatment-naïve, immune-mediated neurological disorders. Although the evidence base has been growing in the last decade, limited understanding has led to confusion, mistrust and increasing use of health tourism. In this article, we discuss what autologous HSCT is, which immune-mediated conditions can be treated with it, how to select patients, what are the expected outcomes and potential adverse effects, and how cost-effective this treatment is.

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Item Type:	Article
Authors/Creators:	Brittain, G. https://orcid.org/0000-0002-9903-7203 Coles, A.J. Giovannoni, G. https://orcid.org/0000-0001-9995-1700 Muraro, P.A. https://orcid.org/0000-0002-3822-1218 Palace, J. Petrie, J. Roldan, E. Scolding, N.J. https://orcid.org/0000-0001-9177-1043 Snowden, J.A. https://orcid.org/0000-0001-6819-3476 Sharrack, B.
Copyright, Publisher and Additional Information:	© Author(s) (or their employer(s)) 2022. This is an author-produced version of a paper subsequently published in Practical Neurology. This version is distributed under the terms of the Creative Commons Attribution-NonCommercial Licence (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes.
Keywords:	multiple sclerosis; myasthenia; neuroimmunology; neuropathy; stiff man syndrome
Dates:	Published: 18 October 2023 Published (online): 26 September 2022 Accepted: 26 August 2022
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	09 Mar 2023 12:44
Last Modified:	25 Sep 2024 11:53
Status:	Published
Publisher:	BMJ
Refereed:	Yes
Identification Number:	10.1136/pn-2022-003531
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:197173

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Autologous haematopoietic stem cell transplantation for immune-mediated neurological diseases: what, how, who and why?

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