GCH1 deficiency activates brain innate immune response and impairs tyrosine hydroxylase homeostasis

Larbalestier, H., Keatinge, M., Watson, L. et al. (15 more authors) (2022) GCH1 deficiency activates brain innate immune response and impairs tyrosine hydroxylase homeostasis. The Journal of Neuroscience, 42 (4). pp. 702-716. ISSN 0270-6474

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Item Type: Article
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© 2022 The Author(s). Reproduced in accordance with the publisher's self-archiving policy. This article is distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: GTP cyclohydrolase 1; Parkinson's disease; microglia; tetrahydrobiopterin; tyrosine hydroxylase; zebrafish; Animals; Animals, Genetically Modified; Brain; Dopaminergic Neurons; GTP Cyclohydrolase; Genetic Predisposition to Disease; Homeostasis; Immunity, Innate; Parkinson Disease; Sequence Analysis, RNA; Tyrosine 3-Monooxygenase; Zebrafish
Dates:
  • Published: 26 January 2022
  • Published (online): 7 December 2021
  • Accepted: 3 November 2021
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield)
Funding Information:
Funder
Grant number
MEDICAL RESEARCH COUNCIL
MR/R011354/1
Depositing User: Symplectic Sheffield
Date Deposited: 28 Feb 2023 10:52
Last Modified: 28 Feb 2023 10:52
Status: Published
Publisher: Society for Neuroscience
Refereed: Yes
Identification Number: 10.1523/jneurosci.0653-21.2021
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