The Role of Non-essential Amino Acids in T Cell Function and Anti-tumour Immunity

Abstract

T cell activation, differentiation and proliferation is dependent upon and intrinsically linked to a capacity to modulate and adapt cellular metabolism. Antigen-induced activation stimulates a transcriptional programme that results in metabolic reprogramming, enabling T cells to fuel anabolic metabolic pathways and provide the nutrients to sustain proliferation and effector responses. Amino acids are key nutrients for T cells and have essential roles as building blocks for protein synthesis as well as in numerous metabolic pathways. In this review, we discuss the roles for uptake and biosynthesis of non-essential amino acids in T cell metabolism, activation and effector function. Furthermore, we highlight the effects of amino acid metabolism and depletion by cancer cells on T cell anti-tumour function and discuss approaches to modulate and improve T cell metabolism for improved anti-tumour function in these nutrient-depleted microenvironments.

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Item Type:	Article
Authors/Creators:	Carrasco Hope, H Salmond, RJ https://orcid.org/0000-0002-1807-1056
Copyright, Publisher and Additional Information:	© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/
Keywords:	Non-essential amino acid; Metabolism; T cell; Immunotherapy; Tumour microenvironment
Dates:	Published: December 2021 Published (online): 12 October 2021 Accepted: 3 September 2021
Institution:	The University of Leeds
Depositing User:	Symplectic Publications
Date Deposited:	23 Feb 2023 11:06
Last Modified:	23 Feb 2023 11:06
Status:	Published
Publisher:	Springer
Identification Number:	10.1007/s00005-021-00633-6
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:196711

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The Role of Non-essential Amino Acids in T Cell Function and Anti-tumour Immunity

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