Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, β-Glucuronidase and Heparanase**

Doherty, Gareth G., Ler, Geraldine Jia Ming, Wimmer, Norbert et al. (9 more authors) (2023) Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, β-Glucuronidase and Heparanase**. Chembiochem. e202200619. ISSN 1439-7633

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Doherty, Gareth G.
  • Ler, Geraldine Jia Ming
  • Wimmer, Norbert
  • Bernhardt, Paul V.
  • Ashmus, Roger A.
  • Vocadlo, David J.
  • Armstrong, Zachary (za675@york.ac.uk)
  • Davies, Gideon J. ORCID logo https://orcid.org/0000-0002-7343-776X
  • Maccarana, Marco
  • Li, Jin ping
  • Kayal, Yasmin
  • Ferro, Vito
Copyright, Publisher and Additional Information:

Funding Information: We gratefully acknowledge support from the Australian Research Council (DP170104431 to V.F.). G.G.D. acknowledges financial support from the University of Queensland Ph.D. scholarship program. G.J.D. is supported by the Royal Society Ken Murray Research Professorship. The Natural Sciences and Engineering Council of Canada (RGPIN‐05426 to D.J.V.). D.J.V. was supported as a Tier I Canada Research Chair in Chemical Biology. The authors also thank the Centre for High‐Throughput Chemical Biology (HTCB) for access to core facilities. We thank Sean Cuskelly for technical assistance and Prof. Israel Vlodavsky and Dr. Maurice Petitou for useful discussions. Open Access publishing facilitated by The University of Queensland, as part of the Wiley ‐ The University of Queensland agreement via the Council of Australian University Librarians. Funding Information: We gratefully acknowledge support from the Australian Research Council (DP170104431 to V.F.). G.G.D. acknowledges financial support from the University of Queensland Ph.D. scholarship program. G.J.D. is supported by the Royal Society Ken Murray Research Professorship. The Natural Sciences and Engineering Council of Canada (RGPIN-05426 to D.J.V.). D.J.V. was supported as a Tier I Canada Research Chair in Chemical Biology. The authors also thank the Centre for High-Throughput Chemical Biology (HTCB) for access to core facilities. We thank Sean Cuskelly for technical assistance and Prof. Israel Vlodavsky and Dr. Maurice Petitou for useful discussions. Open Access publishing facilitated by The University of Queensland, as part of the Wiley - The University of Queensland agreement via the Council of Australian University Librarians. Publisher Copyright: © 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.
Keywords: azasugars,glucuronidases,heparanases,iduronidases,inhibitors,MPS I
Dates:
  • Published: 14 February 2023
  • Published (online): 3 January 2023
  • Accepted: 1 December 2022
Institution: The University of York
Academic Units: The University of York > Faculty of Sciences (York) > Chemistry (York)
Funding Information:
Funder
Grant number
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
BB/R001162/1
THE ROYAL SOCIETY
RSRP\R\210004
Depositing User: Pure (York)
Date Deposited: 22 Feb 2023 12:40
Last Modified: 16 Oct 2024 19:04
Published Version: https://doi.org/10.1002/cbic.202200619
Status: Published
Refereed: Yes
Identification Number: 10.1002/cbic.202200619
Related URLs:
Open Archives Initiative ID (OAI ID):

Download

Published Version

Filename: ChemBioChem_2022_Doherty_Synthesis_of_Uronic_Acid_1_Azasugars_as_Putative_Inhibitors_of_Iduronidase_.pdf

Description: ChemBioChem - 2022 - Doherty - Synthesis of Uronic Acid 1‐Azasugars as Putative Inhibitors of ‐Iduronidase

Licence: CC-BY-NC 2.5

CLICK TO DOWNLOAD [thumbnail of ChemBioChem - 2022 - Doherty - Synthesis of Uronic Acid 1‐Azasugars as Putative Inhibitors of ‐Iduronidase]

Export

Statistics


CORE (COnnecting REpositories)