4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors

Borlandelli, Valentina, Armstrong, Zachary, Nin-Hill, Alba et al. (6 more authors) (2023) 4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors. ChemMedChem. e202200580. ISSN 1860-7187

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Borlandelli, Valentina
  • Armstrong, Zachary (za675@york.ac.uk)
  • Nin-Hill, Alba
  • Codée, Jeroen D.C.
  • Raich, Lluís
  • Artola, Marta
  • Rovira, Carme
  • Davies, Gideon J. ORCID logo https://orcid.org/0000-0002-7343-776X
  • Overkleeft, Herman S.
Copyright, Publisher and Additional Information:

Funding Information: The authors are grateful for funding from the European Research Council (ERC‐2020‐SyG‐951231 Carbocentre, to C. R., G. J. D. and H. S. O.) and the EU‐Horizon 2020‐Marie Curie Action (ITN814102 Sweet Crosstalk, to H. S. O.), the Spanish Ministry of Science, Innovation and Universities (MICINN/AEI/FEDER, UE, PID2020‐118893GB‐100, to C. R.) and the Spanish Structures of Excellence María de Maeztu (MDM‐2017‐0767, to C. R.). G. J. D. is funded by the Royal Society Ken Murray research Professorship. Z. A. was funded in York on BBSRC grant BB/R001162/1. We thank Diamond Light Source for access to beamline I03 (proposal mx24948), which contributed to the results presented here. C. R. and A. N. H. would like to acknowledge the technical support provided by the Barcelona Supercomputing Center (BSC) and Red Nacional de Supercomputación (RES) for computer resources at MareNostrum IV. Publisher Copyright: © 2022 The Authors. ChemMedChem published by Wiley-VCH GmbH.

Keywords: carbohydrates,cyclitols,inhibitors
Dates:
  • Published: 14 February 2023
  • Published (online): 24 January 2023
  • Accepted: 16 December 2022
Institution: The University of York
Academic Units: The University of York > Faculty of Sciences (York) > Chemistry (York)
Funding Information:
Funder
Grant number
EUROPEAN COMMISSION
951231
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
BB/R001162/1
THE ROYAL SOCIETY
RSRP\R\210004
Depositing User: Pure (York)
Date Deposited: 22 Feb 2023 11:20
Last Modified: 22 Oct 2024 00:07
Published Version: https://doi.org/10.1002/cmdc.202200580
Status: Published
Refereed: Yes
Identification Number: 10.1002/cmdc.202200580
Related URLs:
Open Archives Initiative ID (OAI ID):

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