Motlhale, Melitah, Muchengeti, Mazvita, Bradshaw, Debbie et al. (10 more authors) (2023) Kaposi sarcoma-associated herpesvirus, HIV-1 and Kaposi sarcoma risk in black South Africans diagnosed with cancer during antiretroviral treatment rollout. International Journal of Cancer. ISSN 1097-0215
Abstract
Abstract Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma (KS). The risk of KS is amplified in HIV-immunosuppressed individuals and antiretroviral therapy (ART) reduces KS incidence. Reliable data on the relationship between these factors are lacking in Africa. We used questionnaires and serum from 7886 black South Africans (18-74 years) with incident cancer, recruited between 1995 and 2016. ART rollout started in 2004. We measured associations between KS, HIV-1 and KSHV before and after ART rollout. We measured seropositivity to HIV-1, KSHV latency-associated nuclear antigen (LANA) and glycoprotein (K8.1) and calculated case-control-adjusted odds ratios (ORadj) and 95CI) in relation to KS and KSHV infection, before (1995-2004), early (2005-2009) and late (2010-2016) ART rollout periods. KSHV seropositivity among 1237 KS cases was 98649 controls, KSHV seropositivity was higher in males (ORadj = 1.4 [95.23-1.52]), in persons with HIV, (ORadj = 4.2 [95.74-4.73]) and lower in high school leavers (ORadj = 0.7 [95.59-0.83]). KSHV seropositivity declined over the three ART rollout periods (37 288 Ptrend
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©2023 The Authors |
Keywords: | HIV,Kaposi sarcoma,Kaposi sarcoma associated herpesvirus,seropositivity,South Africa |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 22 Feb 2023 10:40 |
Last Modified: | 16 Oct 2024 19:04 |
Published Version: | https://doi.org/10.1002/ijc.34454 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/ijc.34454 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:196690 |
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Description: Intl Journal of Cancer - 2023 - Motlhale - Kaposi sarcoma‐associated herpesvirus HIV‐1 and Kaposi sarcoma risk in black
Licence: CC-BY-NC-ND 2.5