Eachus, H., Ryu, S., Placzek, M. orcid.org/0000-0002-4106-9229 et al. (1 more author) (2022) Zebrafish as a model to investigate the CRH axis and interactions with DISC1. Current Opinion in Endocrine and Metabolic Research, 26. 100383. ISSN 2451-9650
Abstract
Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response systems. Complex feedback loops operate in the HPA axis and understanding the neurobiological mechanisms regulating CRH neurons is of great importance in the context of stress disorders. In this article, we review how in vivo studies in zebrafish have advanced knowledge of the neurobiology of CRH neurons. Disrupted-in-schizophrenia 1 (DISC1) mutant zebrafish have blunted stress responses and can be used to model human stress disorders. We propose that DISC1 influences the development and functioning of CRH neurons as a mechanism linking DISC1 to psychiatric disorders.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | CRF; CRH; DISC1; HPA axis; HPI axis; Hypothalamus; Zebrafish |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) |
Funding Information: | Funder Grant number WELLCOME TRUST (THE) 212247/Z/18/Z |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 23 Feb 2023 11:19 |
Last Modified: | 23 Feb 2023 11:34 |
Published Version: | http://dx.doi.org/10.1016/j.coemr.2022.100383 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.coemr.2022.100383 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:196603 |
Download
Filename: Zebrafish as a model to investigate the CRH axis and interactions with DISC1.pdf
Licence: CC-BY 4.0