Duff, Lee, Meakin, Harry, Richardson, Adam et al. (5 more authors) (2023) Denitrative Hydroxylation of Unactivated Nitroarenes**. Chemistry - A European Journal. e202203807. ISSN 1521-3765
Abstract
A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalization protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and computational studies suggest that nitroarenes may be substituted by an electron-catalysed radical-nucleophilic substitution (SRN1) chain mechanism.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Funding Information: The authors would like to thank the University of York, the University of Manchester, the Leverhulme Trust (for an Early Career Fellowship, ECF‐2019‐135, M.J.J.) and the Royal Society (Research Grant RGS\R1\201268) for financial support. We would also like to thank Dr Jason Lynam, Dr William Unsworth and Prof. Peter O'Brien for helpful discussions. Publisher Copyright: © 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH. |
Keywords: | denitrative functionalisation,hydroxylation,nitroarenes,radical anion,S1 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 17 Feb 2023 16:50 |
Last Modified: | 26 Nov 2024 00:56 |
Published Version: | https://doi.org/10.1002/chem.202203807 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/chem.202203807 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:196544 |
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