Hall, B., George, J.G. and Allen, S.P. (2022) Adenosine deaminase, not immune to a mechanistic rethink in central nervous system disorders? Histology and Histopathology, 37 (3). pp. 189-212. ISSN 0213-3911
Abstract
Adenosine deaminase (ADA) is a purine metabolism enzyme that catalyses the breakdown of adenosine and deoxyadenosine. The enzyme is important in several cellular processes, including the innate immune response and cellular differentiation, and it is also an important enzyme for the maintenance of brain homeostasis, in part due to its regulation of adenosine. Aberrant regulation of ADA enzyme activity has been l i nked t o several neurodegenerat i ve di seases and diseases that can result in neurological impairment. However, t he mechani sms behi nd al t er ed ADA regulation and how this leads to the development of neurological dysfunction are poorly characterised. This review summarises the current research on ADA and its role and regulation in disease pathology, with a focus on t he cent r al ner vous syst em ( CNS) and t he neurodegenerative disease, amyotrophic lateral sclerosis (ALS).
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © The Author(s) 2022. Open Access. This article is licensed under a Creative Commons CC-BY International License. (http://creativecommons.org/licenses/by/4.0) |
Keywords: | Adenosine; Adenosine Deaminase; Amyotrophic Lateral Sclerosis; Brain; Humans; Neurodegenerative Diseases; Central nervous system; Pathology; Severe combined immunodeficiency |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) |
Funding Information: | Funder Grant number ACADEMY OF MEDICAL SCIENCES SBF005\1064 Academy of Medical Sciences SBF005\1064 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 15 Feb 2023 10:07 |
Last Modified: | 16 Feb 2023 14:58 |
Status: | Published |
Publisher: | University of Murcia |
Refereed: | Yes |
Identification Number: | 10.14670/HH-18-404 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:196419 |