Stepankova, K, Mareková, D, Kubášová, K et al. (9 more authors) (2023) 4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats. International Journal of Molecular Sciences, 24 (4). 3799. ISSN 1661-6596
Abstract
4-methylumbelliferone (4MU) has been suggested as a potential therapeutic agent for a wide range of neurological diseases. The current study aimed to evaluate the physiological changes and potential side effects after 10 weeks of 4MU treatment at a dose of 1.2 g/kg/day in healthy rats, and after 2 months of a wash-out period. Our findings revealed downregulation of hyaluronan (HA) and chondroitin sulphate proteoglycans throughout the body, significantly increased bile acids in blood samples in weeks 4 and 7 of the 4MU treatment, as well as increased blood sugars and proteins a few weeks after 4MU administration, and significantly increased interleukins IL10, IL12p70 and IFN gamma after 10 weeks of 4MU treatment. These effects, however, were reversed and no significant difference was observed between control treated and 4MU-treated animals after a 9-week wash-out period.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 by the authors. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | hyaluronan; 4-methylumbelliferone; chondroitin sulphates; neuroplasticity |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) MR/S011110/1 MRC (Medical Research Council) RG84584 MRC (Medical Research Council) MC_PC_16050 Wings For Life Spinal Cord Research Foundation WFL-UK-008/15 Wings For Life Spinal Cord Research Foundation WFL-UK-008/15 Proj 118 |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Feb 2023 15:03 |
Last Modified: | 25 Jun 2023 23:15 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/ijms24043799 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:196406 |