Synthesis, biochemical characterization, and genetic encoding of a 1,2,4‐triazole amino acid as an acetyllysine mimic for bromodomains of the BET family

Kirchgäßner, S., Braun, M.B., Bartlick, N. et al. (5 more authors) (2023) Synthesis, biochemical characterization, and genetic encoding of a 1,2,4‐triazole amino acid as an acetyllysine mimic for bromodomains of the BET family. Angewandte Chemie International Edition, 62 (12). e202215460. ISSN 1433-7851

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Kirchgäßner, S.
  • Braun, M.B.
  • Bartlick, N.
  • Koç, C.
  • Reinkemeier, C.D.
  • Lemke, E.A.
  • Stehle, T.
  • Schwarzer, D.
Copyright, Publisher and Additional Information:

© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (https://creativecommons.org/licenses/by/4.0/).

Keywords: chemical biology; protein modification; lysine acetylation; bromodomain; genetic code expansion
Dates:
  • Published: 13 March 2023
  • Published (online): 9 February 2023
  • Accepted: 31 December 2022
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease
Depositing User: Symplectic Sheffield
Date Deposited: 14 Feb 2023 11:59
Last Modified: 27 Sep 2024 15:00
Status: Published
Publisher: Wiley
Refereed: Yes
Identification Number: 10.1002/anie.202215460
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Open Archives Initiative ID (OAI ID):

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