Stimpson, S., Jenkinson, D.R. orcid.org/0000-0002-2237-4578, Sadler, A. et al. (4 more authors) (2015) Tuning the excited state of water-soluble IrIII-based DNA intercalators that are isostructural with [RuII(NN)2(dppz)] light-switch complexes. Angewandte Chemie International Edition, 54 (10). pp. 3000-3003. ISSN 1433-7851
Abstract
The synthesis of two new IrIII complexes which are effectively isostructural with well-established [Ru(NN)2-(dppz)]2+ systems is reported (dppz = dipyridophenazine; NN = 2,2′-bipyridyl, or 1,10-phenanthroline). One of these IrIII complexes is tricationic and has a conventional N6 coordination sphere. The second dicationic complex has a N5C coordination sphere, incorporating a cyclometalated analogue of the dppz ligand. Both complexes show good water solubility. Experimental and computational studies show that the photoexcited states of the two complexes are very different from each other and also differ from their RuII analogues. Both of the complexes bind to duplex DNA with affinities that are two orders of magnitude higher than previously reported Ir(dppz)-based systems and are comparable with RuII(dppz) analogues.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of a paper subsequently published in Angewandte Chemie International Edition. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | DNA; cyclometalation; intercalation; iridium; luminescence; DNA; Intercalating Agents; Iridium; Light; Rubidium |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL EP/M015572/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 10 Feb 2023 10:56 |
Last Modified: | 11 Feb 2023 01:28 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201411346 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:196159 |