Yang, Zhongzhen, Zalessky, Illya, Epton, Ryan G et al. (3 more authors) (Accepted: 2023) Ring Expansion Strategies for the Synthesis of Medium Sized Ring and Macrocyclic Sulfonamides. Angewandte Chemie International Edition. ISSN 1433-7851 (In Press)
Abstract
Two new ring expansion strategies are reported for the synthesis of medium sized ring and macrocyclic sulfonamides. Both methods can be performed without using classical protecting groups, with the key ring expansion step initiated by nitro reduction and amine conjugate addition respectively. Each method can be used to make diversely functionalised cyclic sulfonamides in good to excellent yields, in a range of ring sizes. The ring size dependency of the synthetic reactions is in good agreement with the outcomes modelled by Density Functional Theory calculations.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2023 Wiley-VCH GmbH. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 03 Feb 2023 09:50 |
Last Modified: | 09 Dec 2024 00:16 |
Published Version: | https://doi.org/10.1002/anie.202217178 |
Status: | In Press |
Refereed: | Yes |
Identification Number: | 10.1002/anie.202217178 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:195972 |
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Filename: Sulfonamide_RE_paper_ACIE_version_6_REVISION.docx
Description: Sulfonamide RE paper ACIE version 6 REVISION