Harrison, SR orcid.org/0000-0002-7465-2621 and Marzo-Ortega, H orcid.org/0000-0002-9683-3407 (2023) Have Therapeutics Enhanced Our Knowledge of Axial Spondyloarthritis? Current Rheumatology Reports, 25 (3). pp. 56-67. ISSN 1523-3774
Abstract
Purpose of Review
An overview of how the treatment landscape of axial spondyloarthritis (axSpA) has shaped our understanding of the disease.
Recent Findings
Prior to the millennium, non-steroidal anti-inflammatory drugs (NSAIDs) were the only treatment for axSpA, yet only 30% of patients responded and many developed side effects. In 2003, the first biological disease-modifying drug (bDMARD) was licensed for axSpA which substantially improved outcomes in comparison to NSAIDs. In 2022, there are now several bDMARDs for axSpA; however, they too are not universally efficacious in treating axial inflammation and may have deleterious effects on extramusculoskeletal manifestations. Nevertheless, successful or not, each bDMARD gives invaluable insight into axSpA immunobiology.
Summary
This review discusses how much we have learned from the use of bDMARDs in axSpA, how this has redefined our understanding of the disease, and how we might use this knowledge to develop new and better treatments for axSpA in the future.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
Keywords: | Axial spondyloarthritis; Ankylosing spondylitis; Biological disease-modifying antirheumatic drugs (bDMARDs); Therapeutics |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust R127002 |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Feb 2023 15:44 |
Last Modified: | 25 Jun 2023 23:14 |
Status: | Published |
Publisher: | Springer |
Identification Number: | 10.1007/s11926-023-01097-7 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:195844 |