Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach

Michelet, R., Bindellini, D., Melin, J. et al. (7 more authors) (2023) Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach. Frontiers in Pharmacology, 13. 1090554. ISSN 1663-9812

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Item Type: Article
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© 2023 Michelet, Bindellini, Melin, Neumann, Blankenstein, Huisinga, Johnson, Whitaker, Ross and Kloft. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms (https://creativecommons.org/licenses/by/4.0/).

Keywords: hydrocortisone; congenital adrenal hyperplasia; population pharmacokinetics; middle-out approach; pediatrics; physiologically-based pharmacokinetics (PBPK); non-linear mixed effects modelling (NLME); maturation
Dates:
  • Published: 12 January 2023
  • Published (online): 12 January 2023
  • Accepted: 23 December 2022
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > The Medical School (Sheffield) > Division of Genomic Medicine (Sheffield) > Department of Oncology and Metabolism (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 31 Jan 2023 14:13
Last Modified: 31 Jan 2023 14:13
Published Version: http://dx.doi.org/10.3389/fphar.2022.1090554
Status: Published
Publisher: Frontiers Media SA
Refereed: Yes
Identification Number: 10.3389/fphar.2022.1090554
Open Archives Initiative ID (OAI ID):

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