Marshall, H. orcid.org/0000-0002-7425-1449, Wild, J.M., Smith, L.J. orcid.org/0000-0002-5769-423X et al. (4 more authors) (2023) Functional imaging in asthma and COPD: design of the NOVELTY ADPro substudy. ERJ Open Research, 9 (1). 00344. ISSN 2312-0541
Abstract
The NOVEL observational longiTudinal studY (NOVELTY; ClinicalTrials.gov identifier: NCT02760329) is a global, prospective, observational study of ∼12 000 patients with a diagnosis of asthma and/or chronic obstructive pulmonary disease (COPD). Here we describe the design of the Advanced Diagnostic Profiling (ADPro) substudy of NOVELTY being conducted in a subset of ∼180 patients recruited from two primary care sites in York, UK. ADPro is employing a combination of novel functional imaging and physiological and metabolic modalities to explore structural and functional changes in the lungs, and their association with different phenotypes and endotypes.
Patients participating in the ADPro substudy will attend two visits at the University of Sheffield, UK, 12±2 months apart, at which they will undergo imaging and physiological lung function testing. The primary endpoints are the distributions of whole lung functional and morphological measurements assessed with Xenon-129 magnetic resonance imaging, including ventilation, gas transfer and airway microstructural indices. Physiological assessments of pulmonary function include spirometry, bronchodilator reversibility, static lung volumes via body plethysmography, transfer factor of the lung for carbon monoxide, multiple-breath nitrogen washout and airway oscillometry. Fractional exhaled nitric oxide will be measured as a marker of Type-2 airways inflammation.
Regional and global assessment of lung function using these techniques will enable more precise phenotyping of patients with physician-assigned asthma and/or COPD. These techniques will be assessed for their sensitivity to markers of early disease progression.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©The authors 2023. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 (http://creativecommons.org/licenses/by-nc/4.0/). For commercial reproduction rights and permissions contact permissions@ersnet.org |
Keywords: | asthma; chronic obstructive pulmonary disease; magnetic resonance imaging; small airways dysfunction; ventilation heterogeneity; Xenon-129 |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection, Immunity and Cardiovascular Disease |
Funding Information: | Funder Grant number ASTRAZENECA PLC D4250C00079 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 30 Jan 2023 16:05 |
Last Modified: | 30 Jan 2023 16:05 |
Published Version: | http://dx.doi.org/10.1183/23120541.00344-2022 |
Status: | Published |
Publisher: | European Respiratory Society (ERS) |
Refereed: | Yes |
Identification Number: | 10.1183/23120541.00344-2022 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:195782 |