Bilyk, B.L., Panchal, V.V., Tinajero-Trejo, M. et al. (2 more authors) (2022) An interplay of multiple positive and negative factors governs methicillin resistance in Staphylococcus aureus. Microbiology and Molecular Biology Reviews, 86 (2). e0015921. ISSN 1092-2172
Abstract
The development of resistance to β-lactam antibiotics has made Staphylococcus aureus a clinical burden on a global scale. MRSA (methicillin-resistant S. aureus) is commonly known as a superbug. The ability of MRSA to proliferate in the presence of β-lactams is attributed to the acquisition of mecA, which encodes the alternative penicillin binding protein, PBP2A, which is insensitive to the antibiotics. Most MRSA isolates exhibit low-level β-lactam resistance, whereby additional genetic adjustments are required to develop high-level resistance. Although several genetic factors that potentiate or are required for high-level resistance have been identified, how these interact at the mechanistic level has remained elusive. Here, we discuss the development of resistance and assess the role of the associated components in tailoring physiology to accommodate incoming mecA.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 American Society for Microbiology. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | MRSA; MecA; Staphylococcus aureus; antimicrobial resistance; Anti-Bacterial Agents; Bacterial Proteins; Humans; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Penicillin-Binding Proteins; Staphylococcal Infections; Staphylococcus aureus |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Physics and Astronomy (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL EP/T002778/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Jan 2023 13:32 |
Last Modified: | 25 Jan 2023 13:32 |
Status: | Published |
Publisher: | American Society for Microbiology |
Refereed: | Yes |
Identification Number: | 10.1128/mmbr.00159-21 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:195524 |