Mullin, E., Aristotelidou, V., Blackburn, D. orcid.org/0000-0001-8886-1283 et al. (2 more authors) (2019) Cognitive deficits in vasculitis of the nervous system: a cross-sectional study. Postgraduate Medicine, 131 (7). pp. 546-549. ISSN 0032-5481
Abstract
Objectives: To identify the cognitive and functional deficits in a well-characterized group of patients with vasculitis of the nervous system.
Methods: Sixty-seven patients diagnosed with Central Nervous System (CNS) or Peripheral nervous System (PNS) vasculitis over a 14-year period were retrospectively identified. Data on clinical presentation, laboratory, radiographic and tissue biopsy investigations, and treatment were collated. Cognitive, functional and quality of life evaluation assessments were performed in 31 patients who agreed to participate and included Addenbrooke’s Cognitive Examination-revised (ACE-R), Nottingham Extended Activities of Daily Living (NEADL) and EQ-5D-3L quality of life questionnaires.
Results: CNS vasculitis patients exhibited cognitive impairment, with a mean ACE-R score of 74/100 (standard deviation (SD) 16). NEADL and EQ-5D-3L scores were in the impaired range at 41/66 (SD 21) and 57/81 (SD 22), respectively. Patients with just PNS vasculitis exhibited fewer cognitive deficits with ACE-R and NEADL scores of 87 (SD 8) and 46 (SD 16) respectively. EQ-5D-3L score was in the impaired range of 65 (SD 22).
Conclusions: Vasculitis of the nervous system and, in particular, CNS vasculitis causes cognitive impairment and deficits in functional ability. Such patients should be targeted for cognitive rehabilitation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Informa UK Limited, trading as Taylor & Francis Group. This is an author-produced version of a paper subsequently published in Postgraduate Medicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | CNS vasculitis; PNS vasculitis; angiitis of the CNS and PNS; cognitive decline; long term consequences; quality of life; Activities of Daily Living; Adult; Aged; Aged, 80 and over; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Female; Giant Cell Arteritis; Granulomatosis with Polyangiitis; Health Status; Humans; Immunosuppressive Agents; Male; Middle Aged; Peripheral Nervous System Diseases; Quality of Life; Retrospective Studies; Vasculitis; Vasculitis, Central Nervous System; Young Adult |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Neuroscience (Sheffield) The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jan 2023 17:17 |
Last Modified: | 19 Jan 2023 13:23 |
Status: | Published |
Publisher: | Informa UK Limited |
Refereed: | Yes |
Identification Number: | 10.1080/00325481.2019.1664256 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:195428 |