Zhang, P orcid.org/0000-0003-3159-3374, Walko, M orcid.org/0000-0002-7160-6136 and Wilson, A orcid.org/0000-0001-9852-6366 (2023) Rational Design of Harakiri (HRK)-Derived Constrained Peptides as BCL-xL inhibitors. Chemical Communications, 59 (12). ISSN 1359-7345
Abstract
Using the HRK BH3 domain, sequence hybridization and in silico methods we show dibromomaleimide staple scanning can be used to inform the design of BCL-xL selective peptideomimetic ligands. These HRK-inspired reagents may serve as starting points for the discovery of therapeutics to target BCL-xL-overexpressed cancers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2023. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Jan 2023 12:25 |
Last Modified: | 26 Jun 2023 13:47 |
Status: | Published |
Publisher: | RSC |
Identification Number: | 10.1039/D2CC06029A |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:195384 |
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