Ratcovich, Hanna, Alkhalil, Mohammad, Beska, Benjamin et al. (5 more authors) (2022) Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome:An ICON-1 sub-study. IJC Heart & Vasculature. 101118. ISSN 2352-9067
Abstract
Background: Cardiovascular disease is the leading cause of mortality for females globally, yet females are underrepresented in studies of acute coronary syndrome (ACS). Studies investigating sex-related differences in clinical outcomes of patients with non-ST elevation ACS (NSTEACS) have reported divergent results, and it is unknown whether long-term outcomes for older people with NSTEACS differ between males and females. Methods: The multi-centre prospective cohort study, ICON-1, consisted of patients aged ≥75 years undergoing coronary angiography following NSTEACS. The primary composite endpoint was all-cause mortality, myocardial infarction, unplanned revascularisation, stroke, and bleeding. We report outcomes at five-years by sex. Results: Of 264 patients, 102 (38.6%) females and 162 (61.4%) males completed the five-year follow-up and were included in the analytic cohort. At admission, females were older than males (82 ± 4.3 years vs 80.0 ± 4.1 years p = 0.018). Co-morbidity profile and GRACE score were similar between the groups. There were no differences in the provision of invasive or pharmacological treatments between sexes. At five-years, there were no association between sex and the primary outcome. Conclusion: In older adults with invasive treatment of NSTEACS, provision of guideline-indicated care and long-term clinical outcomes were similar between males and females.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 09 Nov 2022 11:50 |
Last Modified: | 30 Mar 2025 00:10 |
Published Version: | https://doi.org/10.1016/j.ijcha.2022.101118 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.ijcha.2022.101118 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:193159 |
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Description: Sex differences in long-term outcomes in older adults undergoing invasive treatment for non-ST elevation acute coronary syndrome: An ICON-1 sub-study
Licence: CC-BY-NC-ND 2.5