Arumuga-Nainar, D, Krishna Naik, V orcid.org/0000-0002-8013-7554, Ramadoss, R et al. (2 more authors) (2024) Evaluation of CD44 antigen in type 2 diabetic patients with periodontitis: An immunohistochemical study. Dental and Medical Problems. ISSN 1644-387X
Abstract
Background. Type 2 diabetes mellitus (DM) is a known systemic risk factor for periodontitis. An increased expression of CD44 has been suggested in type 2 diabetics and periodontitis patients.
Objectives. The present study aimed to assess the expression of CD44 antigen in patients with chronic periodontitis (CP) and type 2 DM in a South Indian urban population. Additionally, the relationships between the expression of CD44 antigen in gingival tissues, periodontal clinical parameters, and the random blood sugar (RBS) and glycated hemoglobin (HbA1c) levels were assessed.
Material and methods. A total of 63 subjects were divided into 3 groups: systemically and periodontally healthy controls (group H); CP patients, otherwise healthy (group CP); and CP patients with type 2 DM (group CP+DM). Periodontal parameters were recorded for all groups, and additionally the RBS and HbA1c levels for group CP+DM. Gingival tissue samples were obtained and subjected to immunohistochemical analysis for CD44.
Results. The expression of CD44 was significantly higher in the diseased groups. Epithelial CD44 expression was significantly stronger in group CP+DM as compared to groups CP and H (p < 0.001), whereas connective tissue CD44 expression was similar in groups CP and CP+DM (p = 0.657). Furthermore, an inverse relationship was observed between blood glucose parameters and CD44 expression in the epithelium and connective tissue.
Conclusions. The expression of CD44 increased with the severity of periodontal disease. Additionally, glycemic control in patients with CP and type 2 DM had an impact on CD44 expression. Our findings indicate a possible destructive role of CD44 in the pathogenesis of periodontal diseases in individuals with type 2 DM.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © by Author(s). This is an open access article under the terms of the Creative Commons Attribution 3.0 Unported License (CC-BY 3.0). |
Keywords: | diabetes mellitus, hyaluronan receptors, immunohistochemistry/methods, periodontitis, etiology |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Restorative Dentistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Nov 2022 15:39 |
Last Modified: | 16 Apr 2024 14:13 |
Status: | Published online |
Publisher: | Wroclaw Medical University Press |
Identification Number: | 10.17219/dmp/156225 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:193155 |