Larvin, H orcid.org/0000-0001-7263-4182, Kang, J orcid.org/0000-0002-2770-1099, Aggarwal, VR orcid.org/0000-0003-0838-9682 et al. (2 more authors) (2023) Periodontitis and risk of immune-mediated systemic conditions: a systematic review and meta-analysis. Community Dentistry and Oral Epidemiology, 51 (5). pp. 705-717. ISSN 0301-5661
Abstract
Introduction
The aim of this review is to examine and quantify the long-term risk of immune-mediated systemic conditions in people with periodontitis compared to people without periodontitis.
Methods
Medline, EMBASE and Cochrane databases were searched up to June 2022 using keywords and MeSH headings. The ‘Risk of Bias in Non-Randomised Studies of Interventions’ tool was used to assess bias. Cohort studies comparing incident metabolic/autoimmune/inflammatory diseases in periodontitis to healthy controls were included. Meta-analysis and meta-regression quantified risks and showed impact of periodontitis diagnosis type and severity.
Results
The search retrieved 3354 studies; 166 studies were eligible for full-text screening, and 30 studies were included for review. Twenty-seven studies were eligible for meta-analysis. The risks of diabetes, rheumatoid arthritis (RA) and osteoporosis were increased in people with periodontitis compared to without periodontitis (diabetes—relative risk [RR]: 1.22, 95% CI: 1.13–1.33; RA—RR: 1.27, 95% CI: 1.07–1.52; osteoporosis—RR: 1.40, 95% CI: 1.12–1.75). Risk of diabetes showed gradient increase by periodontitis severity (moderate—RR = 1.20, 95% CI = 1.11–1.31; severe—RR = 1.34, 95% CI = 1.10–1.63).
Conclusion
People with moderate-to-severe cases of periodontitis have the highest risk of developing diabetes, while the effect of periodontal severity on risk of other immune-mediated systemic conditions requires further investigation. More homologous evidence is required to form robust conclusions regarding periodontitis-multimorbidity associations.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. Community Dentistry and Oral Epidemiology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | arthritis, cohort studies, diabetes, immune response, periodontitis, systematic review, systemic disease |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Applied Health and Clinical Translation (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Surgery (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Nov 2022 15:58 |
Last Modified: | 22 Aug 2024 13:51 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/cdoe.12812 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:192890 |