Silva Terra, Ana, Rossetto, Matheus, Dickson, Claire et al. (3 more authors) (2023) Enhancing 19F benchtop NMR spectroscopy by combining parahydrogen hyperpolarisation and multiplet refocusing. ACS Measurement Science Au. pp. 73-81. ISSN 2694-250X
Abstract
Benchtop NMR spectrometers provide a promising alternative to high-field NMR for applications that are limited by instrument size and/or cost. 19F benchtop NMR is attractive due to the larger chemical shift range of 19F relative to 1H and the lack of background signal in most applications. However, practical applications of benchtop 19F NMR are limited by its low sensitivity due to the relatively weak field strengths of benchtop NMR spectrometers. Here we present a sensitivity-enhancement strategy that combines SABRE (Signal Amplification By Reversible Exchange) hyperpolarisation with the multiplet refocusing method SHARPER (Sensitive, Homogeneous, And Resolved PEaks in Real time). When applied to a range of fluoropyridines, SABRE-SHARPER achieves overall signal enhancements of up to 5700-fold through the combined effects of hyperpolarisation and line-narrowing. This approach can be generalised to the analysis of mixtures through the use of a selective variant of the SHARPER sequence, selSHARPER. The ability of SABRE-selSHARPER to simultaneously boost sensitivity and discriminate between two components of a mixture is demonstrated, where selectivity is achieved through a combination of selective excitation and the choice of polarisation transfer field during the SABRE step.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC EP/M020983/1 EPSRC EP/R028745/1 |
Depositing User: | Pure (York) |
Date Deposited: | 27 Oct 2022 13:30 |
Last Modified: | 13 Dec 2024 00:10 |
Published Version: | https://doi.org/10.1021/acsmeasuresciau.2c00055 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acsmeasuresciau.2c00055 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:192704 |