Cayla, Mathieu orcid.org/0000-0002-3731-7947, Nievas, Y. Romina, Matthews, Keith R. et al. (1 more author) (2022) Distinguishing functions of trypanosomatid protein kinases. Trends in parasitology. pp. 950-961. ISSN 1471-4922
Abstract
Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their different hosts could reveal optimal drug-control strategies. Protein kinases are fundamental to many biological processes such as cell cycle control, adaptation to stress, and cellular differentiation. Therefore, we have focused this review on the features and functions of protein kinases that distinguish trypanosomatid kinomes from other eukaryotes. We describe the latest research, highlighting similarities and differences between two groups of trypanosomatid parasites, Leishmania and African trypanosomes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). |
Keywords: | cell cycle,differentiation,protein kinase |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 26 Oct 2022 09:40 |
Last Modified: | 22 Jan 2025 00:20 |
Published Version: | https://doi.org/10.1016/j.pt.2022.08.009 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.pt.2022.08.009 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:192625 |
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Description: Distinguishing functions of trypanosomatid protein kinases
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