Johnson, TC and Marsden, SP orcid.org/0000-0002-2723-8954 (2022) Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids. Journal of Organic Chemistry, 87 (21). pp. 13891-13894. ISSN 0022-3263
Abstract
A convenient and simple three-component synthesis of substituted pyridylacetic acid derivatives is reported. The approach centers on the dual reactivity of Meldrum’s acid derivatives, initially as nucleophiles to perform substitution on activated pyridine-N-oxides, then as electrophiles with a range of nucleophiles to trigger ring-opening and decarboxylation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. Published by American Chemical Society. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY). |
Keywords: | Alcohols, Amines, Organic compounds, Reaction products, Substitution reactions |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Oct 2022 09:50 |
Last Modified: | 25 Jun 2023 23:07 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acs.joc.2c01597 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:192320 |